Strychnine tree

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Strychnos nux-vomica is an evergreen tree native to southeast Asia, especially India and Myanmar, and cultivated elsewhere. Its dried seeds or beans, and sometimes its bark (called nux vomica) are used in herbal remedies. The seeds contain organic substances, strychnine and brucine, that are used in herbal remedies.
It is a major source of the highly poisonous alkaloids strychnine and brucine, derived from the seeds inside the tree’s round, green to orange fruit. The seeds contain approximately 1.5% strychnine, and the dried blossoms contain 1.023%.[1] However, the tree’s bark also contains poisonous compounds

Other Names
-Poison Nut. Semen strychnos. Quaker Buttons,Nux Vomica

Parts Used :- Dried ripe seeds.

habitat: Burma, China, eastern India, Thailand, and northern Australia.

Pharmacology:
Nux Vomica contains the alkaloids, Strychnine and Brucine, also traces of strychnicine, and a glucoside Loganin, about 3 per cent fatty matter, caffeotannic acid and a trace of copper. The pulp of the fruit contains about 5 per cent of loganin together with the alkaloid strychnicine.

Medicinal Uses:
The propertiesof Nux Vomica are substantially those of the alkaloid Strychnine. The powdered seeds are employed in atonic dyspepsia. The tincture of Nux Vomica is often used in mixtures – for its stimulant action on the gastro-intestinal tract. In the mouth it acts as a bitter, increasing appetite; it stimulates peristalsis, in chronic constipation due to atony of the bowel it is often combined with cascara and other laxatives with good effects. Strychnine, the chief alkaloid constituent of the seeds, also acts as a bitter, increasing the flow of gastric juice; it is rapidly absorbed as it reaches the intestines, after which it exerts its characteristic effects upon the central nervous system, the movements of respiration are deepened and quickened and the heart slowed through excitation of the vagal centre. The senses of smell, touch, hearing and vision are rendered more acute, it improves the pulse and raises blood pressure and is of great value as a tonic to the circulatory system in cardiac failure. Strychnine is excreted very slowly and its action is cumulative in any but small doses; it is much used as a gastric tonic in dyspepsia. The most direct symptom caused by strychnine is violent convulsions due to a simultaneous stimulation of the motor or sensory ganglia of the spinal cord; during the convulsion there is great rise in blood pressure; in some types of chronic lead poisoning it is of great value. In cases of surgical shock and cardiac failure large doses are given up to 1/10 grain by hypodermic injection; also used as an antidote in poisoning by chloral or chloroform. Brucine closely resembles strychnine in its action, but is slightly less poisonous, it paralyses the peripheral motor nerves. It is said that the convulsive action characteristic of strychnine is absent in brucine almost entirely. It is used in pruritis and as a local anodyne in inflammations of the external ear.

In cases of poisoning by strychnine an emetic or the stomach pump should be used at once and tannin or potassium permanganate given to render the strychnine inactive. Violent convulsions should be controlled by administration of chloroform or large doses of chloral or bromide. Urethane in large doses is considered an antidote. Amyl nitrite is also useful owing to its rapid action during the convulsion, and in absence of respiration 3 to 5 minims may be hypodermically injected.

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